Non-cell-autonomous effects yield lower clonal diversity in expanding tumors
نویسندگان
چکیده
منابع مشابه
Non-cell autonomous tumor-growth driving supports sub-clonal heterogeneity
Cancers arise through a process of somatic evolution that can result in substantial sub-clonal heterogeneity within tumors. The mechanisms responsible for the coexistence of distinct subclones and the biological consequences of this coexistence remain poorly understood. Here we used a mouse xenograft model to investigate the impact of sub-clonal heterogeneity on tumor phenotypes and the competi...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-11562-w